A large study of Veterans Affairs (VA) patients in JAMA Internal Medicine shows that, during the 2022 to 2023 season, having COVID-19 was associated with more severe disease outcomes than flu or respiratory syncytial virus (RSV) infection. Differences became less pronounced, however, during the 2023 to 2024 season.
Although many of the infections have been mild, emerging data indicate that variants of the avian influenza virus H5N1 that are spreading in North America can cause severe disease and death, especially when passed directly to humans from birds. The virus is also adapting to new hosts — cows and other mammals — raising the risk that it could spark a human pandemic.
...In terms of its effectiveness in preventing deaths, our analysis of the data shows that influenza vaccination is able to reduce infection-associated mortality by half overall, including H3N2 infections.
In its regular weekly snapshot on respiratory virus activity, the Centers for Disease Control and Prevention (CDC) said that illness levels remain high, mainly due to impacts from the flu season.